The building in Husova Street is located in the old Jewish town. According to the painted beams in Mannerist style, the building can be dated back to the reign of Rudolf II. At that time, the house must have been owned by one of the best-placed Jewish bourgeoisie. Since the house had its own synagogue in the courtyard, and from many other sources, it can be assumed that the famous scholar Rabbi Yehuda Löw ben Bezalel, or by the Hebrew acronym מהר״ל - MaHaRaL (Morenu Ha-Rav Liva or also Morenu Ha-gadol Rabi Liva, our (great) teacher Rabbi Liva, lived here.) He spent most of his life here in Mikulov as the Moravian Provincial Rabbi. In 1573 he went to Prague, where he worked at the court of Emperor Rudolf II and became the creator of the legendary Golem.
During the reign of the Ditrichstein family, the house was listed as the property of the Michelsteters, a wealthy Jewish family. Prince Ditrichstein, the owner of Mikulov, kept a protective hand over his Jewish subjects. In 1845 there were more than 3,500 Jewish inhabitants in Mikulov. All the houses were connected, and also in both walls and on both floors of the Michelsteters' house a walled door was found that led to the neighbors.
In the 1930s, the family donated the house to the Jewish community, which set up a home for elderly Jews in the house, and it operated there until 1939. The Jewish population in Mikulov overwhelmingly did not survive the Holocaust and the German population was expelled in 1945.

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